The need to revisit lipid areas

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Proceedings titleJournal Of Physics
ConferenceInternational Conference on Neutron Scattering 2009, May 3-7, 2009, Knoxville, Tennessee
Pages14; # of pages: 4
AbstractWe have studied the structural properties of lipid bilayers made up of monounsaturated phosphatidylcholines (i.e. diCn:1PC, where n=14, 16, 18, 20, 22 and 24). High-resolution x-ray scattering data were analyzed in conjunction with contrast varied neutron scattering data, using the recently developed technique by Ku_erka et al. [Biophys. J. 95, 2356 (2008)]. Analyses of the data show that with increasing n lipid bilayers do not thicken in a linear fashion, as is often assumed, but quadratically, and that lipid area assumes a maximum value for n~18 bilayers. More importantly, compared to previous data our results strongly suggest that lipid areas are smaller by about 10%. This observation highlights the need to revisit lipid areas as they are extensively used in molecular dynamics simulations and for calibrating their force fields.
Publication date
AffiliationNRC Canadian Neutron Beam Centre; National Research Council Canada
Peer reviewedYes
NPARC number16945673
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Record identifiera8fe39fa-2818-4ce7-98bb-0a97baaae465
Record created2011-03-03
Record modified2016-05-09
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