Advanced EWOD-based digital microfluidic system for multiplexed analysis of biomolecular interactions

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DOIResolve DOI: http://doi.org/10.1109/MEMSYS.2011.5734384
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TypeArticle
Proceedings title2011 IEEE 24th International Conference on Micro Electro Mechanical Systems (MEMS)
Conference24th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2011), Jan. 23-27, 2011, Cancun, Mexico
Pages153156; # of pages: 4
AbstractThis paper presents a low-cost technique for the fabrication of complex electrowetting-on-dielectric (EWOD) digital microfluidic devices. Using this original technology, we have developed devices in which 560 electrodes are used to mix and split nl-size liquid droplets and transport them to 100 analysis spots patterned on a disposable plastic top plate. We demonstrate the multiplexing capability of the developed devices by creating on-chip arrays of droplets with various concentration gradients. Finally, automated biomolecular immobilization and hybridization assays are performed in nl-size droplets under numerous conditions simultaneously with only a limited number of stock solutions.
Publication date
LanguageEnglish
AffiliationNRC Industrial Materials Institute; National Research Council Canada
Peer reviewedYes
NRC number54398
NPARC number19434926
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Record identifieraaa87999-1462-42c2-88f3-567c0f5f1eb4
Record created2012-02-17
Record modified2016-05-09
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