Natural product-like chemical space: search for chemical dissectors of macromolecular interactions

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DOIResolve DOI: http://doi.org/10.1016/j.cbpa.2005.04.007
AuthorSearch for: ; Search for:
TypeArticle
Journal titleCurrent Opinion in Chemical Biology
Volume9
Issue3
Pages240247; # of pages: 8
AbstractMacromolecular interactions (i.e. protein�protein or DNA/RNA� protein interactions) play important cellular roles, including cellular communication and programmed cell death. Smallmolecule chemical probes are crucial for dissecting these highly organized interactions, for mapping their function at the molecular level and developing new therapeutics. The lack of ideal chemical probes required to understand macromolecular interactions is the missing link in the next step of dissecting such interactions. Unfortunately, the classical combinatorialchemistry community has not successfully provided the required probes (i.e. natural product inspired chemical probes that are rich in stereochemical and three-dimensional structural diversity) to achieve these goals. The emerging area of diversity-oriented synthesis (DOS) is beginning to provide natural product-like chemical probes that may be useful in this arena.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
NPARC number12328837
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Record identifierab82814a-a667-4dea-8e69-f5002e7ac617
Record created2009-09-10
Record modified2016-05-09
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