Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system

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TypeArticle
Journal titleNat.Immunol.
Volume9
Issue2
Pages137145; # of pages: 9
SubjectBlood-Brain Barrier; Brain; Canada; cell; Cell Adhesion; CELLS; EXPRESSION; In Vitro; Laboratories; lipid; MOLECULE; Monocytes; Multiple; POTENTIAL; RESTRICTED; SYSTEM; TARGET
AbstractAdhesion molecules of the immunoglobulin superfamily are crucial effectors of leukocyte trafficking into the central nervous system. Using a lipid raft-based proteomic approach, we identified ALCAM as an adhesion molecule involved in leukocyte migration across the blood-brain barrier (BBB). ALCAM expressed on BBB endothelium localized together with CD6 on leukocytes and with BBB endothelium transmigratory cups. ALCAM expression on BBB cells was upregulated in active multiple sclerosis and experimental autoimmune encephalomyelitis lesions. Moreover, ALCAM blockade restricted the transmigration of CD4(+) lymphocytes and monocytes across BBB endothelium in vitro and in vivo and reduced the severity and delayed the time of onset of experimental autoimmune encephalomyelitis. Our findings indicate an important function for ALCAM in the recruitment of leukocytes into the brain and identify ALCAM as a potential target for the therapeutic dampening of neuroinflammation
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberCAYROL2007A
NPARC number9374893
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Record identifierab93a2bc-2d37-44b3-94c1-d637def19f11
Record created2009-07-10
Record modified2016-05-09
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