Enhancement and degradation of the R 2 * relaxation rate resulting from the encapsulation of magnetic particles with hydrophilic coatings

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DOIResolve DOI: http://doi.org/10.1002/mrm.22944
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TypeArticle
Journal titleMagnetic Resonance in Medicine
ISSN0740-3194
Volume66
Issue6
Pages17591766; # of pages: 8
Subjectcontrast medium; superparamagnetic iron oxide nanoparticle; article; degradation; diffusion coefficient; encapsulation; hydrogel; hydrophilicity; material coating; Monte Carlo method; nuclear magnetic resonance imaging; particle size; probability; surface property
AbstractThe effects of including a hydrophilic coating around the particles are studied across a wide range of particle sizes by performing Monte Carlo simulations of protons diffusing through a system of magnetic particles. A physically realistic methodology of implementing the coating by cross boundary jump scaling and transition probabilities at the coating surface is developed. Using this formulation, the coating has three distinct impacts on the relaxation rate: an enhancement at small particle sizes, a degradation at intermediate particle sizes, and no effect at large particles sizes. These varied effects are reconciled with the underlying dephasing mechanisms by using the concept of a full dephasing zone to present a physical picture of the dephasing process with and without the coating for all sizes. The enhancement at small particle sizes is studied systemically to demonstrate the existence of an optimal ratio of diffusion coefficients inside/outside the coating to achieve maximal increase in the relaxation rate. Copyright © 2011 Wiley Periodicals, Inc.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Steacie Institute for Molecular Sciences (SIMS-ISSM)
Peer reviewedYes
NPARC number21271438
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Record identifierabc90833-c9ee-4464-9673-f3b29f032b99
Record created2014-03-24
Record modified2016-05-09
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