Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation

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DOIResolve DOI: http://doi.org/10.1136/ard.2004.030429
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TypeArticle
Journal titleAnnals of the Rheumatic Diseases
Volume64
Issue6
Pages808815; # of pages: 8
SubjectCathepsin B; Cysteine; pathology; pha; Protease; Protein; Proteins
AbstractBackground: AA amyloidosis develops in patients with chronic inflammatory diseases. The AA amyloid proteins are proteolytic fragments obtained from serum amyloid A (SAA). Previous studies have provided evidence that endosomes or lysosomes might be involved in the processing of SAA, and contribute to the pathology of AA amyloidosis
Publication date
AffiliationNRC Biotechnology Research Institute; National Research Council Canada
Peer reviewedNo
NRC number47475
NPARC number3539900
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Record identifierac215f7b-bfbc-4f34-9665-a09caa96df44
Record created2009-03-01
Record modified2016-05-09
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