Identification of a transcript encoding a soluble form of toll-like receptor 5 (TLR5) in Atlantic salmon during Aeromonas salmonicida infection

Alternative titleIdentification of a transcript encoding a soluble form of toll-like receptor 5 (TLR5) in the liver of Atalantic salmon infected with Aeromonas salmonicida
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DOIResolve DOI: http://doi.org/10.1016/j.vetimm.2005.05.013
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TypeArticle
Journal titleVeterinary Immunology and Immunopathology
Volume109
Issue1-2
Pages183187; # of pages: 5
Subjectsoluble toll-like receptor; leucine-rich-repeats; LRR; inflammation; Atlantic salmon
AbstractToll-like receptors (TLRs) are involved in the innate immune response against microbial pathogens in vertebrates and insects. The extracellular region of a TLR recognizes pathogen-associated molecules, while the intracellular region initiates the signaling pathway leading to immune response. Membrane-bound TLRs have been found in most vertebrates, but few soluble forms have been reported. A novel transcript corresponding to a portion of a soluble TLR was identified in liver of infected Atlantic salmon. The complete coding sequence of this TLR was obtained and BLASTN analysis showed the highest sequence identity to a recently described full-length cDNA sequence of a soluble TLR5 from rainbow trout (GenBank Accession No.: AB062504). The deduced protein is 40% identical to the mammalian counterpart of the leucine-rich repeat (LRR)/LRR-like motifs of TLR5. Based on the structure of human TLRs, it contains 21 LRRs with conserved LxxLxLxxNx*xx*xxxxFxxL pattern. Since TLR5 is essential for the recognition of bacterial flagellins, we hypothesize that flagellin and perhaps some other pathogen-derived factors from Aeromonas salmonicida bind to this soluble TLR through an unknown binding domain within the LRR.
Publication date
PublisherElsevier
Copyright noticeCopyright © 2005 Elsevier B.V. All rights reserved.
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Marine Biosciences
Peer reviewedYes
NRC number55506
1641
NPARC number3538328
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Record identifierac471292-ff11-41c9-b867-e8310357ac41
Record created2009-03-01
Record modified2016-05-09
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