Siphonols A–E : novel nitric oxide inhibitors from Orthosiphon stamineus of Indonesia

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DOIResolve DOI: http://doi.org/10.1016/S0960-894X(02)00854-5
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TypeArticle
Journal titleBioorganic and Medicinal Chemistry Letters
ISSN0960-894X
Volume13
Issue1
Pages3135; # of pages: 5
AbstractFrom the methanolic extract of Orthosiphon stamineus, four novel highly oxygenated isopimarane-type diterpenes named siphonols A–D (1–4) and a novel biogenetically interesting norisopimarane-type diterpene named siphonol E (5) were isolated. The new compounds 1–3 and 5 showed more potent inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells than a positive control NG-monomethyl-l-arginine (l-NMMA). Siphonols A–E (1–5) represent the first examples of isopimaranes oxygenated at C-20.
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LanguageEnglish
Peer reviewedYes
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NPARC number21274454
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Record identifieraccfb612-8aa0-4cdd-bc61-53b98ffa8792
Record created2015-03-13
Record modified2016-05-09
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