Inhibition of NO production by highly-oxygenated diterpenes of Orthosiphon stamineus and their structure–activity relationship

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DOIResolve DOI: http://doi.org/10.1248/bpb.26.468
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TypeArticle
Journal titleBiological and Pharmaceutical Bulletin
ISSN0918-6158
1347-5215
Volume26
Issue4
Pages468473; # of pages: 6
Subjectnitric oxide (NO) inhibition; structure–activity relationship; diterpenes; isopimarane-type; staminane-type; Orthosiphon stamineus
AbstractNitric oxide (NO) has been implemented in various pathological processes. In the present study, 47 highly-oxygenated isopimarane-type and novel carbon framework staminane-type diterpenes isolated from Orthosiphon stamineus of Indonesia, Okinawa, Myanmar and Vietnam were evaluated for their inhibitory activity in NO production by lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure–activity relationshis were established.
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LanguageEnglish
Peer reviewedYes
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NPARC number21274451
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Record identifierae12c115-e982-4bad-bbcd-9d9a260f2d02
Record created2015-03-13
Record modified2016-05-09
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