Cloning of GLUT3 cDNA from Atlantic cod (Gadus morhua) and expression of GLUT1 and GLUT3 in response to hypoxia

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DOIResolve DOI: http://doi.org/10.1016/j.bbaexp.2005.07.001
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TypeArticle
Journal titleBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression
Volume1730
Issue3
Pages245252; # of pages: 8
SubjectAtlantic cod; glucose transporter; Gadus morhua; GLUT1; GLUT3; hypoxia
AbstractA putative facilitative glucose transporter, GLUT3, cDNA was cloned from Atlantic cod. It is ubiquitously expressed, with substantial levels in kidney. The 519 aa protein has the highest sequence identity (66.3%) to grass carp GLUT3. Atlantic cod were exposed to a hypoxic challenge (45% DO2) for 24 h and the effects on GLUT1 and GLUT3 expression assessed. GLUT1 expression in gill is upregulated; however, in spleen, there is a significant decrease in both GLUT1 and GLUT3 expression. The increase in GLUT1 mRNA is considered to be associated with an increased energy demand on gill, whereas, the decrease in gene expression in spleen potentially reflects a general decrease in rates of transcription.
Publication date
PublisherElsevier
Copyright noticeCrown copyright © 2005
LanguageEnglish
AffiliationNRC Institute for Marine Biosciences; National Research Council Canada; Aquatic and Crop Resource Development
Peer reviewedYes
NRC number42451
1417
NPARC number3538454
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Record identifierae47fee5-8d62-4922-b234-86bebecd7b0a
Record created2009-03-01
Record modified2016-05-09
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