Chronic kidney disease of unknown aetiology and ground-water ionicity : study based on Sri Lanka

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DOIResolve DOI: http://doi.org/10.1007/s10653-014-9641-4
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TypeArticle
Journal titleEnvironmental Geochemistry and Health
ISSN0269-4042
Volume7
Issue2
Pages221231; # of pages: 11
AbstractHigh incidence of chronic kidney disease of unknown aetiology (CKDU) in Sri Lanka is shown to correlate with the presence of irrigation works and rivers that bring-in 'nonpoint source' fertilizer runoff from intensely agricultural regions. We review previous attempts to link CKDU with As, Cd and other standard toxins. Those studies (e.g. the WHO-sponsored study), while providing a wealth of data, are inconclusive in regard to aetiology. Here, we present new proposals based on increased ionicity of drinking water due to fertilizer runoff into the river system, redox processes in the soil and features of 'tank'-cascades and aquifers. The consequent chronic exposure to high ionicity in drinking water is proposed to debilitate the kidney via a Hofmeister-type (i.e. protein-denaturing) mechanism.
Publication date
LanguageEnglish
AffiliationSecurity and Disruptive Technologies; National Research Council Canada
Peer reviewedYes
NPARC number21272928
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Record identifierb0dc53f7-00e5-4f5b-bc87-8bf20c17dc6e
Record created2014-12-03
Record modified2016-05-09
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