Time-of-flight Bragg scattering from aligned stacks of lipid bilayers using the Liquids Reflectometer at the Spallation Neutron Source

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DOIResolve DOI: http://doi.org/10.1107/S0021889812039945
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TypeArticle
Journal titleJournal of Applied Crystallography
ISSN0021-8898
1600-5767
Volume45
Issue6
Pages12191227; # of pages: 9
Subjecttime-of-flight neutron diffraction; Spallation Neutron Source; Liquids Reflectometer; lipid bilayers
AbstractTime-of-flight (TOF) neutron diffraction experiments on aligned stacks of lipid bilayers using the horizontal Liquids Reflectometer at the Spallation Neutron Source are reported. Specific details are given regarding the instrumental setup, data collection and reduction, phase determination of the structure factors, and reconstruction of the one-dimensional neutron scattering length density (NSLD) profile. The validity of using TOF measurements to determine the one-dimensional NSLD profile is demonstrated by reproducing the results of two well known lipid bilayer structures. The method is then applied to show how an antimicrobial peptide affects membranes with and without cholesterol.
Publication date
LanguageEnglish
AffiliationSecurity and Disruptive Technologies; National Research Council Canada
Peer reviewedYes
IdentifierS0021889812039945
NPARC number21269064
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Record identifierb1027399-6580-4cbb-972e-a21548a46120
Record created2013-12-04
Record modified2016-05-09
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