Safety evaluation of calcium administered intranasally to mice

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DOIResolve DOI: http://doi.org/10.1177/1091581809347388
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TypeArticle
Journal titleInternational Journal of Toxicology
Volume28
Issue6
Pages510518; # of pages: 9
Subjectcalcium; intranasal; safety; toxicity; vaccine
AbstractCalcium, a component of approved human vaccines administered via systemic routes, has a good safety profile. Recently, intranasally administered vaccines containing calcium have shown promise in generating mucosal immune responses in animal models. However, the safety of intranasally administered calcium is unknown. This study evaluates the safety of intranasally administered calcium at 2- to 13-fold higher doses than used in experimental vaccines. At a calcium dose of 22 mg/kg, 80% of the Balb/c and 20% of the C57BL/6 mice die within the first 24 hours. At 11.0 mg/kg, there is no overt toxicity in either strain, based on body weight, clinical scores, blood chemistry, and histopathology of major organs at 7 days post administration. In C57BL/6 mice, apart from acute and subacute inflammation in the lungs at up to 3 days post administration, especially at the 22-mg/kg dose, there is no overt toxicity. Doses of calcium up to 11 mg/kg appear to be safe in a mouse model.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Institute for Biological Sciences
Peer reviewedYes
NPARC number15336750
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Record identifierb1aeeebc-a229-46eb-8996-02bb64eeca18
Record created2010-05-21
Record modified2016-05-09
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