Surface modification of nonviral nanocarriers for enhanced gene delivery

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DOIResolve DOI: http://doi.org/10.2217/nnm.13.194
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TypeArticle
Journal titleNanomedicine
ISSN1748-6963
Volume9
Issue1
Pages135151; # of pages: 17
Subjectbiofunctionalization; lateral stabilization; nonviral gene delivery; polymeric coating; responsive teethering; shielding; surface modification
AbstractBiomedical nanotechnology has given a new lease of life to gene therapy with the ever-developing and ever-diversifying nonviral gene delivery nanocarriers. These are designed to pass a series of barriers in order to bring their nucleic acid cargo to the right subcellular location of particular cells. For a given application, each barrier has its dedicated strategy, which translates into a physicochemical, biological and temporal identity of the nanocarrier surface. Different strategies have thus been explored to implement adequate surface identities on nanocarriers over time for systemic delivery. In that context, this review will mainly focus on organic nanocarriers, for which these strategies will be described and discussed.
Publication date
LanguageEnglish
AffiliationHuman Health Therapeutics; National Research Council Canada
Peer reviewedYes
NRC numberNRC-HHT-53218
NPARC number21272291
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Record identifierb2090f29-f135-4bef-a18b-096bec9ad146
Record created2014-07-23
Record modified2016-05-09
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