Isolation and synthetic diversification of jadomycin 4-amino-l-phenylalanine

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DOIResolve DOI: http://doi.org/10.1021/np5009398
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TypeArticle
Journal titleJournal of Natural Products
ISSN0163-3864
Volume78
Issue6
Pages12081214; # of pages: 7
AbstractStreptomyces venezuelae ISP5230 was grown in the presence of phenylalanine analogues to observe whether they could be incorporated into novel jadomycin structures. It was found that the bacteria successfully produced jadomycins incorporating 4-aminophenylalanine enantiomers. Upon isolation and characterization of jadomycin 4-amino-l-phenylalanine (1), it was synthetically derivatized, using activated succinimidyl esters, to yield a small jadomycin amide library. These are the first examples of oxazolone-ring-containing jadomycins that have incorporated an amino functionality subsequently used for derivatization.
Publication date
PublisherACS Publications
LanguageEnglish
AffiliationNational Research Council Canada; Aquatic and Crop Resource Development
Peer reviewedYes
NRC number56153
NPARC number21275909
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Record identifierb235da6e-490d-4cd7-9675-50572f95f5bc
Record created2015-07-31
Record modified2016-05-09
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