Effect of phosphate-based glass fibre surface properties on thermally produced poly(lactic acid) matrix composites

  1. Get@NRC: Effect of phosphate-based glass fibre surface properties on thermally produced poly(lactic acid) matrix composites (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1007/s10856-011-4453-x
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Journal titleJournal of Materials Science: Materials in Medicine
Pages26592672; # of pages: 14
SubjectBone repair; Carbonyl groups; Cell alignment; Chain scission; Cytocompatibility; Dissolution rates; Glass compositions; Inorganic/organic; matrix; Matrix composite; MC3T3-E1; Melt processing; Phosphate based glass; Phosphate-buffered salines; Poly(lactic acid); Polylactic acids; Preosteoblasts; Surface hydroxyl groups; Surface polarities; Bioactive glass; Biodegradable polymers; Biomechanics; Contact angle; Deionized water; Dissolution; Fibers; Glass fibers; Interfacial energy; Lactic acid; Mechanical properties; Polymer matrix composites; Saline water; Silicon compounds; Surface chemistry; Surfaces; Surface properties; carbonyl derivative; glass fiber; iron; phosphate; phosphate buffered saline; polylactic acid; silicon; animal cell; article; bone regeneration; bone remodeling; dissolution; hydrophilicity; mechanics; molecular weight; mouse; nonhuman; osteoblast; priority journal; scanning electron microscopy; structure analysis; surface property; thermal analysis; X ray diffraction
AbstractIncorporation of soluble bioactive glass fibres into biodegradable polymers is an interesting approach for bone repair and regeneration. However, the glass composition and its surface properties significantly affect the nature of the fibre-matrix interface and composite properties. Herein, the effect of Si and Fe on the surface properties of calcium containing phosphate based glasses (PGs) in the system (50P 2O 5-40CaO-(10-x)SiO 2-xFe 2O 3, where x = 0, 5 and 10 mol.%) were investigated. Contact angle measurements revealed a higher surface energy, and surface polarity as well as increased hydrophilicity for Si doped PG which may account for the presence of surface hydroxyl groups. Two PG formulations, 50P 2O 5-40CaO-10Fe 2O 3 (Fe10) and 50P 2O 5-40CaO-5Fe 2O 3-5SiO 2 (Fe5Si5), were melt drawn into fibres and randomly incorporated into poly(lactic acid) (PLA) produced by melt processing. The ageing in deionised water (DW), mechanical property changes in phosphate buffered saline (PBS) and cytocompatibility properties of these composites were investigated. In contrast to Fe10 and as a consequence of the higher surface energy and polarity of Fe5Si5, its incorporation into PLA led to increased inorganic/organic interaction indicated by a reduction in the carbonyl group of the matrix. PLA chain scission was confirmed by a greater reduction in its molecular weight in PLA-Fe5Si5 composites. In DW, the dissolution rate of PLA-Fe5Si5 was significantly higher than that of PLA-Fe10. Dissolution of the glass fibres resulted in the formation of channels within the matrix. Initial flexural strength was significantly increased through PGF incorporation. After PBS ageing, the reduction in mechanical properties was greater for PLA-Fe5Si5 compared to PLA-Fe10. MC3T3-E1 preosteoblasts seeded onto PG discs, PLA and PLA-PGF composites were evaluated for up to 7 days indicating that the materials were generally cytocompatible. In addition, cell alignment along the PGF orientation was observed showing cell preference towards PGF. © 2011 Springer Science+Business Media, LLC.
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AffiliationNational Research Council Canada (NRC-CNRC); NRC Industrial Materials Institute (IMI-IMI)
Peer reviewedYes
NPARC number21271373
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Record identifierb2dd1a53-5224-4d15-aa78-13e10cb88f03
Record created2014-03-24
Record modified2016-05-09
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