Thermodynamic properties of carbocations and carbanions. Solvation effects from an electrochemical and theoretical (AM1) study of some substituted benzyl radicals

Download
  1. Get@NRC: Thermodynamic properties of carbocations and carbanions. Solvation effects from an electrochemical and theoretical (AM1) study of some substituted benzyl radicals (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1021/jo00016a010
AuthorSearch for: ; Search for: ; Search for:
TypeArticle
Journal titleJournal Of Organic Chemistry
ISSN00223263
Volume56
Issue16
Pages48534858; # of pages: 6
AbstractGm phaae ionization potentials (IP) and electron affiiities (EA) for a number substituted benzyl radicaln have been calculated using the AM1 method. There is a remarkably good correlation between the electrochemical oxidation potentials in acetonitrile and the calculated IPS (slope = 1.03, r = 0.995) and between the reduction potentials in acetonitrile and the calculated EA'S (slope = 1.04, r = 0.996). These correlations, which include both monosubstituted radicals and a,para-disubstituted radicals, cover a potential range of ca. 2 eV for both the oxidations and reductions. The relationship between size and solvation energy of a carbocation in acetonitrile is demonstrated. Thus, the solvation free energy of the benzyl cation is ca. -40 kcal mol-¹ while that for the methoxymethyl cation is -56 kcal mol-¹. The data suggest that charge distribution, and not only size, is mponsible for the observed differential solvation effects of the benzylic ions. It is concluded that the a-methoxybenzyl cations have solvation free energies that are at least 8 kcal mol-¹ more exoergonic than either the benzyl or a-cyanobenzyl cations. This solvation effect is the result of a higher localized charge density on the benzylic group in the a-methoxy derivatives. Substituentaubstituent interactions in the disubstituted ions are evaluated by using the electrochemical potentiale to calculate the free energy change for isodesmic electron trensfer reactions. Saturation effects are observed in the interaction of two stabilizing substituents (i.e. two methoxy groups on a cation, two cyano group on a carbanion). Other substituent-substituent effects appear to be eseentiaUy additive.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
Identifier10008226
NPARC number12328864
Export citationExport as RIS
Report a correctionReport a correction
Record identifierb39af098-9f2c-4aec-9d38-1e4c722f54d5
Record created2009-09-10
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)