Real-time control of angioplasty balloon inflation based on feedback from intravascular optical coherence tomography: Experimental validation on an excised heart and a beating heart model

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DOIResolve DOI: http://doi.org/10.1109/TBME.2012.2189884
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TypeArticle
Journal titleIEEE Transactions on Biomedical Engineering
ISSN0018-9294
Volume59
Issue5
Article number6166864
Pages14881495; # of pages: 8
SubjectAngioplasty; Balloon inflation; Beating heart; Coronary arteries; Experimental validations; Feed-back loop; In-vivo; Inflation process; Intravascular; Programmable syringe pump; Real time; Target values; Balloons; Control; Experiments; Optical tomography; Real time control; Heart; animal experiment; artery constriction; article; balloon catheter; control system; controlled study; feedback system; flow rate; heart beat; heart surgery; nonhuman; optical coherence tomography; percutaneous transluminal angioplasty; syringe; Algorithms; Angioplasty, Balloon; Animals; Feedback; Heart; Models, Cardiovascular; Pressure; Swine; Tomography, Optical Coherence
AbstractWe report on real-time control of balloon inflation inside porcine arteries. In the first step, experiments were done in a coronary artery of an excised heart. In the second step, experiments were done in a beating heart setup providing conditions very close to in vivo conditions without the complications. A programmable syringe pump was used to inflate a compliant balloon in arteries, while intravascular optical coherence tomography (IVOCT) monitoring was performed. In a feedback loop, IVOCT images were processed to provide the balloon diameter values in real time to control the pump action in order to achieve a target diameter. In different experiments, various flow rates and target diameters were used. In the excised heart experiment, there was good convergence to target diameters resulting in a satisfactory balloon inflation control. In the beating heart experiment, there were oscillations in the diameter values due to cyclic arterial contractions. In these experiments, the control system maintained diameter averages satisfactorily close to predetermined target values. Real-time control of balloon inflation could not only provide a safer outcome for angioplasty procedures, but could also provide additional information for diagnostics since it implicitly provides information about the artery response to the inflation process. © 1964-2012 IEEE.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Industrial Materials Institute (IMI-IMI)
Peer reviewedYes
NPARC number21269531
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Record identifierb4719974-50af-4298-80ae-eb170904fd63
Record created2013-12-12
Record modified2016-05-09
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