Identification of pectenotoxin-11 as 34S-hydroxypectenotoxin-2, a new pectenotoxin analogue in the toxic donoflagellate Dinophysis acuta from New Zealand

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DOIResolve DOI: http://doi.org/10.1021/tx050240y
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TypeArticle
Journal titleChemical Research in Toxicology
Volume19
Issue2
Pages310318; # of pages: 9
Subjectbiological poisons; coasts; diarrhea; dinoflagellates; enzymes; hepatopancreas; magnetic resonance spectroscopy; marine molluscs; mass spectroscopy; mortality causes; phytoplankton; public health; toxicants; toxicity; toxicity tests; ultraviolet radiation; pectenotoxins; Perna canaliculus; Dinophysis acuta
AbstractA new pectenotoxin, which has been named pectenotoxin-11 (PTX11), was isolated from the dinoflagellate Dinophysis acuta collected from the west coast of New Zealand. The structure of PTX11 was determined as 34S-hydroxypectenotoxin-2 by tandem mass spectrometry and UV and NMR spectroscopy. PTX11 appears to be only the third pectenotoxin identified as a natural biosynthetic product from algae after pectenotoxin-2 and pectenotoxin-12. The LD50 of PTX11 determined by mouse intraperitoneal injection was 244 g/kg. The LDmin of PTX11 in these experiments was 250 g/kg. No signs of toxicity were recorded in mice following an oral dose of PTX11 at 5000 g/kg. No diarrhea was observed in any of the animals administered with the test substance by either route of administration. Unlike pectenotoxin-2 (PTX2), PTX11 was not readily hydrolyzed to its corresponding seco acid by enzymes from homogenized green-lipped mussel (Perna canaliculus) hepatopancreas.
Publication date
PublisherACS Publications
Copyright noticeCopyright © 2006 American Chemical Society
LanguageEnglish
AffiliationNRC Institute for Marine Biosciences; National Research Council Canada; Measurement Science and Standards; Aquatic and Crop Resource Development
Peer reviewedYes
NRC number42555
1628
NPARC number3538365
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Record identifierb4b1270b-03a4-4c00-8dc6-86c38a7e9d52
Record created2009-03-01
Record modified2016-05-09
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