Metabolomics and cheminformatics analysis of antifungal function of plant metabolites

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DOIResolve DOI: http://doi.org/10.3390/metabo6040031
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TypeArticle
Journal titleMetabolites
ISSN2218-1989
Volume6
Issue4
Pages31
SubjectFusarium head blight; Fusarium graminearum; cheminformatics; metabolomics; plant resistance; biotic stress; antifungal; carbonic anhydrase; cytochrome P450
AbstractFusarium head blight (FHB), primarily caused by Fusarium graminearum, is a devastating disease of wheat. Partial resistance to FHB of several wheat cultivars includes specific metabolic responses to inoculation. Previously published studies have determined major metabolic changes induced by pathogens in resistant and susceptible plants. Functionality of the majority of these metabolites in resistance remains unknown. In this work we have made a compilation of all metabolites determined as selectively accumulated following FHB inoculation in resistant plants. Characteristics, as well as possible functions and targets of these metabolites, are investigated using cheminformatics approaches with focus on the likelihood of these metabolites acting as drug-like molecules against fungal pathogens. Results of computational analyses of binding properties of several representative metabolites to homology models of fungal proteins are presented. Theoretical analysis highlights the possibility for strong inhibitory activity of several metabolites against some major proteins in Fusarium graminearum, such as carbonic anhydrases and cytochrome P450s. Activity of several of these compounds has been experimentally confirmed in fungal growth inhibition assays. Analysis of anti-fungal properties of plant metabolites can lead to the development of more resistant wheat varieties while showing novel application of cheminformatics approaches in the analysis of plant/pathogen interactions.
Publication date
LanguageEnglish
AffiliationInformation and Communication Technologies; Aquatic and Crop Resource Development; National Research Council Canada
Peer reviewedYes
NPARC number23001325
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Record identifierb5e2ca59-5938-4ff6-9a8d-e1556f5a0c29
Record created2017-01-17
Record modified2017-01-17
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