A method for detecting forward scattering signals on-chip with a photonic-microfluidic integrated device

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DOIResolve DOI: http://doi.org/10.1364/BOE.4.001051
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TypeArticle
Journal titleBiomedical Optics Express
ISSN2156-7085
Volume4
Issue7
Pages10511060; # of pages: 10
SubjectDesign modifications; False positive rates; Forward scatters; Integrated device; Integrated microfluidic devices; Optimal excitation; Polystyrene beads; Side scatter signal; Geometry; Photoexcitation; Polystyrenes; Signal detection; article; device fabrication; device testing; experimental design; fluorescence imaging; free space detection; laboratory diagnosis; light scattering; limit of detection; microfluidic analysis; optical excitation; optics; scatter detection
AbstractA photonic integrated microfluidic device is demonstrated to perform optical excitation and forward scatter collection all on-chip in a planar format. Integrated on-chip optics formed a tailored beam geometry for optimal excitation of particles while a special design modification allowed for on-chip forward collection with the beam shaping capabilities. A notch was placed in the lens system that caused a dark spot on the facet of a collection waveguide while not affecting the beam geometry at the point of interrogation. The modified device with the ability to form a 10 μm beam geometry was demonstrated to detect the forward scatter from blank 5 μm diameter polystyrene beads. Free-space collection of side scatter signals was performed simultaneously with the on-chip collection and the designs demonstrated and enhanced SNR while the reliability of detection was determined to be appropriate for many applications. Excellent performance was confirmed via a false positive rate of 0.4%, a missed events rate of 6.8%, and a coincident rate of 96.3% as determined between simultaneously performed free-space and on-chip detection schemes. © 2013 Optical Society of America.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21270547
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Record identifierb60201b1-f4c3-46bb-a8e9-c184a1b35768
Record created2014-02-17
Record modified2016-05-09
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