Benzodiazepine receptor involvement in the control of receptive field size and responsiveness in primary somatosensory cortex

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DOIResolve DOI: http://doi.org/10.1016/0006-8993(86)90917-0
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TypeArticle
Journal titleBrain Res.
Volume376
Issue1
Pages194198; # of pages: 5
SubjectS1 cortex; receptive field; benzodiazepine; Ro 15-1788; flurazepam; diazepam; midazoalm
AbstractMicroiontophoretic ejection of 3 benzodiazepines (BZDs), flurazepam, diazepam and midazolam, and of Ro 15-1788 to primary somatosensory cortical neurons altered the nature of the responses evoked by natural stimulation of the cutaneous surface. BZDs raised the thresholds to tactile stimulation and produced a decrease of the receptive field areas of neurons situated in rapidly adapting submodality regions of S1 cortex; these effects of the BZDs were exerted at different apparent potencies. Ro 15-1788 antagonized the BZDinduced receptive field size decreases and threshold changes. When administered alone, this substance sometimes lowered the threshold for tactile activation and slightly enlarged the receptive field size.
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LanguageEnglish
Peer reviewedYes
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NRC numberOKA1986
NPARC number9380446
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Record identifierb71253ee-c28f-4d02-81ec-65ac87a8b518
Record created2009-07-10
Record modified2016-05-09
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