Structural basis for antibody recognition in the receptorbinding domains of toxins a and B from clostridium difficile

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DOIResolve DOI: http://doi.org/10.1074/jbc.M113.505917
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TypeArticle
Journal titleJournal of Biological Chemistry
ISSN0021-9258
Volume289
Issue4
Pages23312343; # of pages: 13
AbstractBackground: TcdA and TcdB are the main virulence factors for Clostridium difficile infections. Results: X-ray crystallography, mass spectrometry, and size exclusion chromatography reveal the molecular basis of antibody recognition. Conclusion: Neutralizing antibodies do not directly block binding to known receptors, suggesting new mechanisms of neutralization. Significance: The molecular details of antibody recognition will assist with the development of novel therapeutics and diagnostics. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); Human Health Therapeutics (HHT-TSH)
Peer reviewedYes
NPARC number21270832
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Record identifierb7672678-50a3-4cef-8022-8a23ad9d4bdf
Record created2014-02-17
Record modified2016-05-09
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