O-Acetylation in the O-specific polysaccharide isolated from Shigella flexneri serotype 2a: Carbohydr.Res.

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TypeArticle
Journal titleCarbohydr.Res.
Volume342
Issue3-4
Pages643647; # of pages: 5
SubjectAcetylation; ANTIGENICITY; Carbohydrate Sequence; CHAIN; chemistry; Child; DISEASE; Glucose; Glycosylation; Human; Infant; LIPOPOLYSACCHARIDE; LPS; Molecular Sequence Data; MOLECULE; Nuclear Magnetic Resonance,Biomolecular; O Antigens; O-SPECIFIC POLYSACCHARIDE; POLYSACCHARIDE; SEROTYPE; Shigella flexneri; Vaccines
AbstractShigella flexneri causes diarrheal diseases especially in infants and children in developing countries. Modifications of the lipopolysaccharide (LPS) molecule, like bacteriophage-mediated glucosylation and acetylation of the O-specific chain (O-SP), are important for the LPS antigenicity and consequently for the immunogenicity of the polysaccharide-based vaccines against shigellosis. Here, we report the degree of O-acetylation and the localisation of O-acetyl groups and side-chain glucose substitution in the O-SP (scheme) in different preparations of S. flexneri type 2a LPS. [structure: see text]
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberKUBLERKIELB2007
NPARC number9360045
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Record identifierb79cf6fb-8f33-4e2c-b0aa-a48884c26135
Record created2009-07-10
Record modified2016-05-09
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