Melanin as a confounding factor in near infrared spectroscopy of skin

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Proceedings titleVibrational Spectroscopy
ConferenceShedding New Light on Disease: Optical Diagnostics for the New Millennium, Winnipeg, Canada, June 25-30, 2000
Pages4552; # of pages: 8
SubjectNear infrared spectroscopy; Melanin; Least squares
AbstractBlood oxygenation and blood volume are two clinically relevant parameters that can be determined noninvasively from near infrared in vivo spectra. As the number of medical applications based on near infrared technology grows, the necessity of extracting the same quality of information from all individuals increases as well. High epidermal melanin content masks the absorption of oxyhemoglobin and deoxyhemoglobin. Near infrared spectra were recorded in vivo from the forearm of subjects with light and highly pigmented skin. The spectra were analyzed using a modified Beer–Lambert Law and a least squares classifier. In the first iteration the analysis included the chromophores oxyhemoglobin, deoxyhemoglobin and water; in the second iteration the analysis included melanin as an additional chromophore. Including melanin in the fit results in a statistically significant (P<0.05) improvement over the analysis without melanin. This is particularly true for the spectra obtained from highly pigmented skin. The residuals for highly pigmented skin decrease by 2 orders of magnitude when melanin is included and by 1 order of magnitude for the spectra obtained from lightly pigmented skin.
Publication date
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NRC number1886
NPARC number9148179
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Record identifierb7b6bd26-8dda-4744-bb2e-7e114c94b61d
Record created2009-06-25
Record modified2016-09-26
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