Chiral separation with molecularly imprinted polysulfone-aldehyde derivatized nanofiber membranes

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DOIResolve DOI: http://doi.org/10.1016/j.memsci.2012.01.033
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TypeArticle
Journal titleJournal of Membrane Science
Volume401-402
Issue15 May 2012
Pages8996; # of pages: 8
SubjectElectrospray deposition; Chiral separation; Membrane; Molecular imprinting; Molecularly imprinted nanofiber membrane; Nanofiber fabric; Optical resolution
AbstractMolecularly imprinted membranes (MIPMs) and molecularly imprinted nanofiber membranes (MINFMs) were prepared from polysulfone with aldehyde (PSf-CHO-05 or PSf-CHO-10) and N- -benzyloxycarbonyl-D-gultamic acid (Z-D-Glu) or N-a-benzyloxycarbonyl-L-glutamic acid (Z-L-Glu) as a print molecule. Those two types of molecularly imprinted membrane, such as MIPMs and MINFMs, incorporated the enantiomer, of which absolute configuration was same as that of the print molecule, in preference to the corresponding antipode. In other words, the membranes imprinted by the D-isomer preferentially adsorbed the D-isomer and vice-versa. Those two types of membrane showed chiral separation ability by membrane transport. Against expectation, transport of the enantiomer less adsorbed in the membrane was selectively transported. The fluxes through the molecularly imprinted nanofiber membranes gave one to two orders of magnitude higher than those of usual molecularly imprinted membranes without depression of permselectivity. The present study demonstrated that molecularly imprinted nanofiber membrane gave high flux without depression of permselectivity. A breakthrough in membrane separation would be realized by adopting molecularly imprinted nanofiber membranes.
Publication date
LanguageEnglish
AffiliationNRC Institute for Chemical Process and Environmental Technology; National Research Council Canada
Peer reviewedYes
NRC number53064
NPARC number19775295
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Record identifierb7efc168-7dc6-4e45-a453-fa922aee9161
Record created2012-04-05
Record modified2016-05-09
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