Modelling the effect of imperfect vaccines on disease epidemiology

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TypeArticle
Journal titleDiscrete and continuous dynamical systems. Series B
Volume4
Issue4
Pages9991012; # of pages: 14
AbstractWe develop a mathematical model to monitor the effect of imperfect vaccines on the transmission dynamics of infectious diseases. It is assumed that the vaccine efficacy is not and may wane with time. The model will be analyzed using a new technique based on some results related to the Poincaré index of a piecewise smooth Jordan curve defined as the boundary of a positively invariant region for the model. Using global analysis of the model, it is shown that reducing the basic reproductive number () to values less than one no longer guarantees disease eradication. This analysis is extended to determine the threshold level of vaccination coverage that guarantees disease eradication.
Publication date
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedNo
NRC number2052
NPARC number9147920
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Record identifierb848a1c7-abe4-4210-9925-976b21d6ce59
Record created2009-06-25
Record modified2016-05-09
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