Stress-induced gene expression in Candida albicans : absence of a general stress response

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DOIResolve DOI: http://doi.org/10.1091/mbc.E02-08-0546
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TypeArticle
Journal titleMolecular Biology of the Cell
Volume14
Issue4
Pages14601467; # of pages: 8
AbstractWe used transcriptional profiling to investigate the response of the fungal pathogen Candida albicans to temperature and osmotic and oxidative stresses under conditions that permitted >60% survival of the challenged cells. Each stress generated the transient induction of a specific set of genes including classic markers observed in the stress responses of other organisms. We noted that the classical hallmarks of the general stress response observed inSaccharomyces cerevisiae are absent from C. albicans; no C. albicans genes were significantly induced in a common response to the three stresses. This observation is supported by our inability to detect stress cross-protection in C. albicans. Similarly, in C. albicans there is essentially no induction of carbohydrate reserves like glycogen and trehalose in response to a mild stress, unlike the situation in S. cerevisiae. Thus C. albicans lacks the strong general stress response exhibited byS. cerevisiae.
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LanguageEnglish
AffiliationNational Research Council Canada; NRC Biotechnology Research Institute
Peer reviewedNo
NPARC number12328563
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Record identifierb9c360e5-b67d-4ba8-b933-8f95f892c52d
Record created2009-09-10
Record modified2016-05-09
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