α-tocopherol’s location in membranes is not affected by their composition

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DOIResolve DOI: http://doi.org/10.1021/la502605c
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TypeArticle
Journal titleLangmuir
ISSN0743-7463
1520-5827
Volume31
Issue15
Pages44644472
AbstractTo this day, α-tocopherol’s (aToc) role in humans is not well known. In previous studies, we have tried to connect aToc’s biological function with its location in a lipid bilayer. In the present study, we have determined, by means of small-angle neutron diffraction, that not only is aToc’s hydroxyl group located high in the membrane but its tail also resides far from the center of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) bilayers. In addition, we located aToc’s hydroxyl group above the lipid backbone in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine (POPS), and sphingomyelin bilayers, suggesting that aToc’s location near the lipid–water interface may be a universal property of vitamin E. In light of these data, how aToc efficiently terminates lipid hydroperoxy radicals at the membrane center remains an open question.
Publication date
PublisherAmerican Chemical Society
LanguageEnglish
AffiliationSecurity and Disruptive Technologies; National Research Council Canada
Peer reviewedYes
NPARC number23001719
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Record identifierb9e52b8c-9218-43d8-bc48-8fd6aba32969
Record created2017-03-21
Record modified2017-03-21
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