Mixed-mode capillary electrokinetic separation of positional explosive isomers using sodium dodecyl sulfate and negative-beta-cyclodextrin derivatives

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DOIResolve DOI: http://doi.org/10.1016/S0021-9673(98)00284-2
AuthorSearch for: ; Search for:
TypeArticle
Journal titleJournal of Chromatography A
Volume811
Issue1-2
Pages225232; # of pages: 8
Subjectenv; Buffer composition; Positional isomer separation; Explosives; Nitrobenzene; Nitrotoluenes
AbstractA mixed-modecapillary electrophoretic technique has been developed for the separation of positional nitroaromatic explosiveisomers. The procedure utilized two different buffer additives as pseudo-stationary phases with different selectivities towards the analytes. Sodiumdodecylsulfate (SDS) displayed selectivities for the explosives which were similar to C18 reversed-phase HPLC. The negatively charged sulfobutyl ether-β-cyclodextrin (SB-β-CD), sulfated-β-CD and succinylated-β-CD separated the explosives on the formation of inclusion complexes with the analytes, and exhibited different selectivities for the explosives compared to SDS. A mixed pseudo-stationary phase was then formulated by combining 10 mM SB-β-CD, 30 mM SDS and 10% acetonitrile in 20 mM borate at pH 9 to resolve the two most difficultly separated pairs: 1,3-dinitrobenzene/1,4-dinitrobenzene and 3-nitrobenzene/4-nitrobenzene.
Publication date
LanguageEnglish
AffiliationNRC Biotechnology Research Institute; National Research Council Canada
Peer reviewedNo
NRC number41787
NPARC number3539357
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Record identifierbae72df1-f80f-459a-8616-bd67951526b8
Record created2009-03-01
Record modified2016-05-09
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