Three new C-14 oxygenated taxanes from the wood of Taxus yunnanensis

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DOIResolve DOI: http://doi.org/10.1021/np020235j
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TypeArticle
Journal titleJournal of Natural Products
ISSN0163-3864
1520-6025
Volume65
Issue11
Pages17001702; # of pages: 3
AbstractThree new C-14 oxygenated taxane-type diterpenes, hongdoushans A−C (1−3), were isolated from the wood of Taxus yunnanensis together with four known diterpenes and two lignans. The absolute stereochemistry of the 2-methylbutyryloxy group attached at C-14 of the taxane skeleton was determined to be S by GC analysis of the methyl ester of 2-methylbutyric acid obtained after alkaline hydrolysis of 1 and 4 followed by treatment with CH2N2. The complete stereostructure of the known compound 2α,5α,10β-triacetoxy-14β-[(S)-2-methylbutyryloxy]-4(20),11-taxadiene (4) was established for the first time. The isolates obtained were evaluated for their antiproliferative activity toward murine colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cell lines.
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LanguageEnglish
Peer reviewedYes
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NPARC number21274774
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Record identifierbbaa7141-f434-49e2-8a93-984300acd246
Record created2015-04-08
Record modified2016-05-09
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