Nonlinear optical measurements of the artery wall: parameters related to the progression of atherosclerosis

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DOIResolve DOI: http://doi.org/10.2478/v10048-009-0018-2
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TypeArticle
Journal titleMeasurement Science Review
Volume9
Issue4
Pages9394; # of pages: 2
SubjectNonlinear optical microscopy, coherent anti-Stokes Raman scattering, two photon excited fluorescence, second harmonic generation, atherosclerosis
AbstractNonlinear optical (NLO) microscopy is used to follow key structural and biochemical changes associated with the progression of atherosclerosis. Arteries from WHHL-MI rabbits are examined using a 3 channel NLO microscope that can simultaneously monitor the coherent anti-stokes Raman scattered light (CARS), the two-photon excited fluorescence (TPEF) and the second harmonic generation (SHG) from a sample. Distinct differences in the nonlinear optical signals are observed that correlate with the age of the vessel and the presence of atherosclerotic plaque. These differences are attributed to the changing extracellular matrix and the increased lipid deposition associated with plaque development. The capability of NLO to perform 3D sectioning in thick highly scattering vessels in order to visualize structural details of the artery wall and highlight vessel pathology is demonstrated. These features make NLO a potentially valuable tool to help understand the progression of atherosclerosis.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; NRC Steacie Institute for Molecular Sciences; National Research Council Canada
Peer reviewedYes
NPARC number19926385
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Record identifierbc9904d4-f91d-4614-8616-caa91eadd3eb
Record created2012-05-10
Record modified2016-05-09
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