Hippocampal membrane-associated p75 ntr levels are increased in alzheimer's Disease

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DOIResolve DOI: http://doi.org/10.3233/JAD-2012-120115
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TypeArticle
Journal titleJournal of Alzheimer's Disease
ISSN1387-2877
Volume30
Issue3
Pages675684; # of pages: 10
Subjectamyloid beta protein[1-42]; neurotrophin receptor p75; adult; aged; Alzheimer disease; article; autopsy; brain tissue; clinical article; cognition; controlled study; female; frontal cortex; hippocampus; human; human cell; human cell culture; human tissue; male; mouse; neuroblastoma cell; nonhuman; priority journal; Aged; Aged, 80 and over; Alzheimer Disease; Cell Line, Tumor; Cell Membrane; Female; Frontal Lobe; Hippocampus; Humans; Male; Middle Aged; Neurons; Receptor, Nerve Growth Factor; Tumor Cells, Cultured
AbstractThe pan-specific p75 neurotrophin receptor (p75 NTR) is believed to play an important role in the pathogenesis of Alzheimer's disease (AD). It is involved in mediating amyloid-β (Aβ) toxicity and stimulating amyloidogenesis. In addition, we have recently shown that stimulating cultured SH-SY5Y human neuroblastoma cells with Aβ 42 increases the level of membrane-associated p75 NTR and that Aβ 42- accumation in two strains of transgenic AD model mice is accompanied by an increased level of hippocampal membrane-associated p75 NTR (Chakravarthy et al. J Alzheimers Dis 19, 915-925, 2010). This raised an important question whether accumulating Aβ 42 in human AD is also accompanied by an increased hippocampal membrane-associated p75 NTR. In this study, using polyclonal and monoclonal antibodies against the p75 NTR receptor's intra-and extracellular domains, we show that indeed the mean level of membrane-associated p75 NTR in the hippocampal formation is significantly higher (~two-fold, p < 0.03) in human AD brains than in identical samples of hippocampal formation in age-matched non-AD human brains. The possible relation of this elevated hippocampal p75 NTR to AD cognitive decline is discussed. © 2012 -IOS Press and the authors.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Institute for Biological Sciences (IBS-ISB)
Peer reviewedYes
NPARC number21269238
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Record identifierbcf39eff-1592-4ba5-8e39-bc6d3a11d6ca
Record created2013-12-12
Record modified2016-05-09
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