Combinatorial chemistry toward understanding the function(s) of carbohydrates and carbohydrate conjugates

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DOIResolve DOI: http://doi.org/10.1002/1521-3765(20010202)7:3<555::AID-CHEM555>3.0.CO;2-I
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TypeArticle
Journal titleChemistry: A European Journal
Volume7
Issue3
Pages555563; # of pages: 9
SubjectArtificial glycopeptides; carbohydrates; combinatorial chemistry; glycoconjugates; glycomimetics
AbstractCombinatorial chemistry has contributed significantly to understanding the structure - function relationships of biologically important molecules such as proteins and nucleic acids. However, carbohydrates and carbohydrate conjugates, which have been identified as key modulators of several biological functions have not enjoyed the same measure of success. The complexity and synthetic challenges of carbohydrate conjugates have resulted in a number of conceptual approaches to rapidly access sufficient quantities of these biomolecules. This article summarizes these combinatorial approaches and also highlights fully automated library synthesis of artificial glycopeptides with the goals of understanding their biological roles.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
NPARC number12341013
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Record identifierbdf018ee-e609-4303-91f6-89b042438edf
Record created2009-09-11
Record modified2016-05-09
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