Effect of cholesterol on the lateral nanoscale dynamics of fluid membranes

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DOIResolve DOI: http://doi.org/10.1007/s00249-012-0826-4
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TypeArticle
Journal titleEuropean Biophysics Journal
ISSN0175-7571
1432-1017
Volume41
Issue10
Pages901913; # of pages: 13
SubjectLipid membrane; Cholesterol; Lateral membrane dynamics; Nanoscale dynamics; Liquid-ordered phase; Inelastic neutron scattering; Dispersion relation
AbstractInelastic neutron scattering was used to study the effect of 5 and 40 mol% cholesterol on the lateral nanoscale dynamics of phospholipid membranes. By measuring the excitation spectrum at several lateral q || values (up to q || = 3 Å−1), complete dispersion curves were determined of gel, fluid and liquid-ordered phase bilayers. The inclusion of cholesterol had a distinct effect on the collective dynamics of the bilayer’s hydrocarbon chains; specifically, we observed a pronounced stiffening of the membranes on the nanometer length scale in both gel and fluid bilayers, even though they were experiencing a higher degree of molecular disorder. Also, for the first time we determined the nanoscale dynamics in the high-cholesterol liquid-ordered phase of bilayers containing cholesterol. Namely, this phase appears to be “softer” than fluid bilayers, but better ordered than bilayers in the gel phase.
Publication date
LanguageEnglish
AffiliationNRC Canadian Neutron Beam Centre; National Research Council Canada
Peer reviewedYes
Identifier826
NPARC number21268349
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Record identifierbecdb5c0-0e23-4b1c-8259-18123364a5fa
Record created2013-06-28
Record modified2016-05-09
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