Synthesis and antihepatotoxic and antiproliferative activities of di- and tri-O-caffeoylquinic acid derivatives

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TypeArticle
Journal titleJournal of traditional medicines
ISSN1340-6302
Volume18
Issue5
Pages183190; # of pages: 8
Subjectcaffeoylquinic acids; synthesis; hepatoprotective activity; antiproliferative activity, murine colon 26-L5 carcinoma
AbstractMethyl di- and tri-O-caffeoylquinates were synthesized by esterification of methyl quinate with di-O-acetylcaffeoyl chloride, following deprotection of the acetyl groups. Moreover, 4,5-di-O-caffeoylquinic acid was synthesized by esterification of quinide with di-O-acetylcaffeoyl chloride, followed by a hydrolysis of product quinide. These synthetic compounds were tested for their hepatoprotective activity on _D-galactosamine (_D-GalN)/tumor necrosis factor-α (TNF- α)-induced cell death in primary cultured mouse hepatocytes, which possessed significant hepatoprotective activity concentration-dependently. The activity was enhanced by the presence of caffeoyl group. On the other hand, they showed only weak antiproliferative activities against murine colon 26-L5 carcinoma, human HT-1080 fibrosarcoma, murine B16-BL6 melanoma, and human lung carcinoma A-549 cells.
Publication date
Linkhttp://ci.nii.ac.jp/naid/110001853166
LanguageEnglish
Peer reviewedYes
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NPARC number21274804
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Record identifierbf33182a-1965-4bec-996e-d2553040afee
Record created2015-04-12
Record modified2016-05-09
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