Monitoring the switch : the Warburg effect and targeted proteomic analysis of cancer metabolism

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DOIResolve DOI: http://doi.org/10.2174/157016412799746263
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TypeArticle
Journal titleCurrent Proteomics
Volume9
Issue1
Pages2639; # of pages: 14
SubjectCancer; glycolysis; MRM; targeted proteomics; warburg effect
AbstractCancer cells dramatically alter their metabolism in order to increase the production rate of intermediates required for nucleic and fatty acid biosynthesis in rapidly proliferating cells. While not well understood, dysregulation of oncogenes and tumour suppressors appears to result in the altered expression of specific isoforms of glycolysis proteins. A full understanding of glycolytic alterations in cancer through a systems biology approach requires tools to observe changes in the set of proteins that make up the glycolytic proteome. We propose that a targeted proteomics approach employing multiple reaction monitoring (MRM) is an excellent startegy to quatitatively monitor sets of proteins, such as those making up the glycolytic proteome. MRM is particularly well suited to proteins of glycolysis as they are of moderate to high abundance. Such systems-based efforts provide a means to understand the mechanisms for an altered glycolytic proteome in cancer, perhaps leading to novel drup targets and metabolic signatures for use in cancer prognosis.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; Aquatic and Crop Resource Development; Human Health Therapeutics
Peer reviewedNo
NRC number51783
NPARC number21268167
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Record identifierbfaa5129-2164-4a04-a502-9c01f3be342f
Record created2013-05-16
Record modified2016-05-09
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