Paraquat induces oxidative stress, neuronal loss in substantia nigra region and Parkinsonism in adult rats : Neuroprotection and amelioration of symptoms by water-soluble formulation of Coenzyme Q₁₀

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DOIResolve DOI: http://doi.org/10.1186/1471-2202-10-88
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TypeArticle
Journal titleBMC Neuroscience
Volume10
Issue88
Pages# of pages: 12
AbstractBackground: Parkinson's disease, for which currently there is no cure, develops as a result of progressive loss of dopamine neurons in the brain; thus, identification of any potential therapeutic intervention for disease management is of a great importance. Results: Here we report that prophylactic application of water-soluble formulation of coenzyme Q₁₀ could effectively offset the effects of environmental neurotoxin paraquat, believed to be a contributing factor in the development of familial PD. In this study we utilized a model of paraquatinduced dopaminergic neurodegeneration in adult rats that received three weekly intra-peritoneal injections of the herbicide paraquat. Histological and biochemical analyses of rat brains revealed increased levels of oxidative stress markers and a loss of approximately 65% of dopamine neurons in the substantia nigra region. The paraquat-exposed rats also displayed impaired balancing skills on a slowly rotating drum (rotorod) evidenced by their reduced spontaneity in gait performance. In contrast, paraquat exposed rats receiving a water-soluble formulation of coenzyme Q₁₀ in their drinking water prior to and during the paraquat treatment neither developed neurodegeneration nor reduced rotorod performance and were indistinguishable from the control paraquat-untreated rats. Conclusion: Our data confirmed that paraquat-induced neurotoxicity represents a convenient rat model of Parkinsonian neurodegeneration suitable for mechanistic and neuroprotective studies. This is the first preclinical evaluation of a water-soluble coenzyme Q₁₀ formulation showing the evidence of prophylactic neuroprotection at clinically relevant doses.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Institute for Biological Sciences
Peer reviewedYes
NPARC number15463777
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Record identifierc19c6eec-0d78-4955-9e53-2f3456755855
Record created2010-08-16
Record modified2016-05-09
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