The effect of growth conditions on in vitro adherence, invasion and NAF expression by Proteus mirabilis 7570

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TypeArticle
Journal titleCanadian Journal of Microbiology
Volume44
Issue9
Pages896904
AbstractProteus mirabilis is a common cause of upper urinary tract infections. Fimbriae-mediated adherence of this organism to urinary tract epithelium and invasion of host cells are factors thought to be important in its pathogenesis. We have assessed the effect of growth in serum, blood, and urine on the ability of P. mirabilis 7570 to adhere to and invade in vitro the cell line EJ/28, derived from a human urinary tract tumour, and to express nonagglutinating fimbriae (NAF). Proteus mirabilis was capable of adhering to EJ/28 cells to varying degrees depending upon the growth conditions used. It was invasive under all conditions, except when grown in urine, and was found to be particularly so when serum or blood was present in the media. Expression of NAF occurred under all growth conditions examined and was limited only by a decrease in temperature.
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PublisherNational Research Council Canada. Research Press
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NRC numberLATTA1998
NPARC number9366493
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Record identifierc1f62653-d3a1-42d6-8b85-a48c411cbe9d
Record created2009-07-10
Record modified2017-07-17
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