A comparison of MR imaging of a mouse model of glioma at 0.2T and 9.4T

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DOIResolve DOI: http://doi.org/10.1016/j.jneumeth.2011.10.030
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TypeArticle
Journal titleJournal of Neuroscience Methods
ISSN01650270
Volume204
Issue1
Pages118123
SubjectMRI; Glioma; Brain; Low field MRI; RF coil
AbstractBoth 0.2 T and 9.4 T MRI systems were used to image a mouse model of glioma. RF coils were designed for both fields. A spin-echo, multi-echo pulse sequence was used to determine T2 relaxation times of both brain and tumor tissues. Contrast-to-noise ratio was calculated based on the selected echo time. The results showed that 0.2 T is suitable for mouse model imaging, however total scan time must be long to achieve high enough SNR. T2 relaxation times of the tumor and brain tissues can be measured at 0.2 T and are 2.1 and 1.8 times respectively longer at 0.2 T than at 9.4 T. Contrast to noise ratio for tumor and brain was better at high field than at the low field. We concluded that 0.2 T may be used to study mouse model of glioma using spin echo pulse sequence, yet the total scan time is long (about 40 min), resolution is lower (∼250 μm × 250 μm) and slice thickness (3 mm) must be large enough to obtain sufficient SNR.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
IdentifierS016502701100656X
NPARC number21268793
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Record identifierc26b08d9-0eaf-41e2-9620-d1f05e2667ca
Record created2013-11-13
Record modified2016-05-09
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