Neuroregenerative strategies in the brain: emerging significance of bonemorphogenetic protein 7 (BMP7)

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DOIResolve DOI: http://doi.org/10.1139/O08-116
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TypeArticle
Journal titleBiochemistry and Cell Biology
Volume86
Issue5
Pages361369; # of pages: 9
SubjectAnimal; Animals; Bone Morphogenetic Protein 7; Brain; Brain Injuries; Canada; Cell Differentiation; Cell Survival; Cell Transplantation; Cytokines; DISEASE; drug therapy; Humans; metabolism; MODEL; Nerve Regeneration; Neurogenesis; Neuroprotective Agents; pathology; physiology; POTENTIAL; PROGRAM; protein; Role; Stroke; therapeutic use; therapy; Tissue Engineering
AbstractEvery year thousands of people suffer from brain injuries and stroke, anddevelop motor, sensory, and cognitive problems as a result of neuronal loss in thebrain. Unfortunately, the damaged brain has a limited ability to enact repair andcurrent modes of treatment are not sufficient to offset the damage. An extensivelist of growth factors, neurotrophic factors, cytokines, and drugs has been exploredas potential therapies. However, only a limited number of them may actually have thepotential to effectively offset the brain injury or stroke-related problems. One ofthe treatments considered for future brain repair is bone morphogenetic protein 7(BMP7), a factor currently used in patients to treat non-neurological diseases. The clinical application of BMP7 is based on its neuroprotective role in stroke animal models. This paper reviews the current approac hes considered for brain repair and discusses the novel convergent strategies by which BMP7 potentially can induce neuroregeneration
Publication date
LanguageEnglish
AffiliationNRC Industrial Materials Institute; NRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberBANIYAGHOUB2008
NPARC number9375333
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Record identifierc2fe6c23-ec49-4ffa-b635-61d6ab480ac3
Record created2009-07-10
Record modified2016-05-09
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