Investigations into the toxicology of Spirolides, a group of marine Phycotoxins

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DOIResolve DOI: http://doi.org/10.3390/toxins4010001
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TypeArticle
Journal titleToxins
Volume4
Issue1
Pages114; # of pages: 14
SubjectSpirolides; marine phycotoxin; acute toxicity; Alexandrium ostenfeldii; seafood poisoning
AbstractSpirolides are marine phycotoxins produced by the dinoflagellates Alexandrium ostenfeldii and A. peruvianum. Here we report that 13-desmethyl spirolide C shows little cytotoxicity when incubated with various cultured mammalian cell lines. When administered to mice by intraperitoneal (ip) injection, however, this substance was highly toxic, with an LD₅₀ value of 6.9 µg/kg body weight (BW), showing that such in vitro cytotoxicity tests are not appropriate for predicting the in vivo toxicity of this toxin. Four other spirolides, A, B, C, and 20-methyl spirolide G, were also toxic to mice by ip injection, with LD50 values of 37, 99, 8.0 and 8.0 µg/kg BW respectively. However, the acute toxicities of these compounds were lower by at least an order of magnitude when administration by gavage and their toxic effects were further diminished when administered with food. These results have implications for future studies of the toxicology of these marine toxins and the risk assessment of human exposure.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Marine Biosciences
Peer reviewedYes
NRC number54075
NPARC number21268141
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Record identifierc32fcc98-3d35-44a0-a513-3ced005e9c74
Record created2013-05-09
Record modified2016-05-09
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