Mass spectral characterization of phloroglucinol derivatives hyperforin and adhyperforin

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DOIResolve DOI: http://doi.org/10.1002/rcm.2650
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TypeArticle
Journal titleRapid Communications in Mass Spectrometry
Volume20
Issue18
Pages26412648; # of pages: 8
Subjectmethods; mass spectrometry; Hypericum perforatum; St. John's wort
AbstractActive phloroglucinol constituents of Hypericum perforatum (St. John's wort) extracts, hyperforin and adhyperforin, have been studied following ion activation using tandem mass spectrometry (MS/MS) and complemented by accurate mass measurements. These two compounds were readily analyzed as protonated and deprotonated molecules with electrospray ionization. MS/MS and MS3 data from a quadrupole-linear ion trap tandem mass spectrometer were employed to elucidate fragmentation pathways. Fourier transform ion cyclotron resonance measurements afforded excellent mass accuracies for the confirmation of elemental formulae of product ions formed via infrared multiphoton dissociation and sustained off-resonance irradiation collision-induced dissociation. Fragmentation schemes have been devised for the dissociation of hyperforin and adhyperforin in negative and positive ion modes. This information is expected to be especially valuable for the characterization of related compounds, such as degradation products, metabolites and novel synthetic analogs of hyperforin.
Publication date
PublisherWiley
Copyright noticeCopyright © 2006 John Wiley & Sons, Ltd.
LanguageEnglish
AffiliationNRC Institute for Marine Biosciences; National Research Council Canada
Peer reviewedYes
IdentifierNRC-ACRD-55906
NRC number1621
NPARC number3538410
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Record identifierc36773eb-543d-4b8e-9fb7-96381d98ed5e
Record created2009-03-01
Record modified2016-05-09
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