Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats

Download
  1. Get@NRC: Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1002/jmri.21856
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleJournal of Magnetic Resonance Imaging
Volume30
Issue2
Pages271276; # of pages: 6
Subjectdiabetes; neuropathy; streptozotocin; rat; fMRI
AbstractPURPOSE: To determine if differences exist between control and diabetic rats in functional magnetic resonance imaging (fMRI) activity of the spinal cord and if fMRI can provide a means of early detection of diabetic neuropathy. MATERIALS AND METHODS: fMRI of the spinal cord, using noxious electrical stimulation (15 V ( approximately 8 mA), 0.3 msec, 3 Hz) of the hind paw, was performed in groups of control and streptozotocin (STZ)-induced type 1 diabetic rats. RESULTS: Diabetic rats were lighter, hyperglycemic, and had lower blood pH than controls. fMRI activity at the lumbar enlargement of the spinal cord was identified in the dorsal horn ipsilateral to stimulus of all animals. Signal intensity changes across the lumbar spinal cord during periods of activity were not significantly different between control and diabetic rats, with a trend toward greater signal changes in controls. When specific regions of the spinal cord were analyzed, control rats exhibited significantly increased blood-oxygen level-dependent (BOLD) fMRI activity in both ipsilateral and contralateral dorsal horn compared to diabetic rats. CONCLUSION: The results of this study are consistent with reports that primary afferent input to the spinal cord is diminished by diabetes, and suggest that BOLD fMRI may be useful in early detection of diabetic neuropathy.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NPARC number20154427
Export citationExport as RIS
Report a correctionReport a correction
Record identifierc5e6aae4-2424-4aae-b749-22d4e906d3cc
Record created2012-06-22
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)