Spontaneously Forming Unilamellar Phospholipid Vesicles

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DOIResolve DOI: http://doi.org/10.1002/masy.200550111
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TypeArticle
Journal titleMacromolecular Symposia
Volume219
Issue1
Pages123134; # of pages: 12
AbstractUnilamellar vesicles (ULV) consisting of a single lipid bilayer are of special interest as drug delivery vehicles. Here, we report on a spontaneously forming ULV system composed of the short- and long-chain phospholipids, dihexanoyl (DHPC) and dimyristoyl (DMPC) phosphorylcholine, respectively, doped with the negatively charged lipid, dimyristoyl phosphorylglycerol (DMPG). Small-angle neutron scattering (SANS) and dynamic light scattering (DLS) were employed to systematically investigate the effects of lipid concentration, salinity, and time on vesicle stability. It is found that ULV size is practically constant over a range of lipid concentration and temperature. The spontaneously formed ULV are stable for periods of four months, or greater, without the use of stabilizers.
Publication date
AffiliationNational Research Council Canada; NRC Canadian Neutron Beam Centre
Peer reviewedNo
NPARC number12330722
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Record identifierc65b0d4e-6239-43b9-8679-7569510125d9
Record created2009-09-10
Record modified2016-05-09
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