Toxicogenomic effects of nano- and bulk-TiO2 particles in the soil nematode Caenorhabditis elegans

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DOIResolve DOI: http://doi.org/10.3109/17435390.2014.948941
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TypeArticle
Journal titleNanotoxicology
ISSN1743-5390
Volume9
Issue4
Pages502512; # of pages: 11
SubjectGene expression; juglone; nanoparticles; oxidative stress; titanium dioxide
AbstractThe toxicity and toxicogenomics of selected anatase and rutile nanoparticles (NP) and bulk titanium dioxide (TiO2) particles were evaluated in the soil nematode Caenorhabditis elegans. Results indicated that bulk or nano-TiO2 particles were slightly toxic to soil nematode C. elegans, as measured by reproduction EC50 values ranging from 4 to 32 mg/L. Whole-genome microarray results indicated that the regulation of glutathione-S-transferase gst-3, cytochrome P450 cypp33-c11, stress resistance regulator scl-1, oxidoreductase wah-1 and embryonic development pod-2 genes were significantly affected by nano-sized and bulk-TiO2 particles. More specifically, it was determined that anatase particles exerted a greater effect on metabolic pathways, whereas rutile particles had a greater effect on developmental processes. The up-regulation of the pod-2 gene corroborated the phenotypic effect observed in the reproduction test. Our results demonstrated that C. elegans is a good genomic model for nano-TiO2 toxicity assessment.
Publication date
LanguageEnglish
AffiliationHuman Health Therapeutics; Energy, Mining and Environment; Aquatic and Crop Resource Development; National Research Council Canada
Peer reviewedYes
NRC number55498
NPARC number21275438
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Record identifierc69cf2ac-cd6d-4830-93b3-47e1c87f18dd
Record created2015-07-13
Record modified2016-05-09
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