The antioxidant efficiency of vitamin C is concentration-dependent

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DOIResolve DOI: http://doi.org/10.1016/0304-4165(86)90234-5
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TypeArticle
Journal titleBiochimica Et Biophysica Acta (BBA) - General Subjects
ISSN0006-3002
Volume884
Issue1
Pages119123; # of pages: 5
SubjectAntioxidants; Ascorbic Acid; Humans; Lipid Peroxides; Models, Chemical; Osmolar Concentration
AbstractThe inhibition of autoxidation of plasma lipids by vitamin C (ascorbic acid) has been studied. The ascorbate stoichiometric factor, n, i.e., the number of peroxyl radicals trapped by each ascorbate molecule, decreases as the concentration of ascorbate increases. This is attributed to the fact that ascorbate not only acts as a radical-trapping antioxidant, but can also undergo autoxidation. The data indicate that n → 2.0 as [ascorbate] → 0 and that n → 0 as [ascorbate] → ∞. This concentration-dependent behaviour accounts for the wide variation of n values reported in the literature. It is suggested that this autoxidative destruction of ascorbate may play a role regulating its concentration in blood plasma.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada
Peer reviewedNo
Identifier10307965
NPARC number12337897
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Record identifierc814f414-d4b8-4826-9798-ec63664fd7f6
Record created2009-09-10
Record modified2016-05-09
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