The structures of the lipooligosaccharide and capsule polysaccharide of Campylobacter jejuni genome sequenced strain NCTC 11168

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DOIResolve DOI: http://doi.org/10.1046/j.1432-1033.2002.03201.x
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TypeArticle
Journal titleEuropean Journal of Biochemistry
Volume269
Issue21
Pages51195136; # of pages: 18
Subjectlipooligosaccharide; capsule; electron spray ionization mass spectrometry; high-resolution magic angle spinning NMR; heptose
AbstractCampylobacter jejuni infections are one of the leading causes of human gastroenteritis and are suspected of being a precursor to Guillain–Barré and Miller–Fisher syndromes. Recently, the complete genome sequence of C. jejuni NCTC 11168 was described. In this study, the molecular structure of the lipooligosaccharide and capsular polysaccharide of C. jejuni NCTC 11168 was investigated. The lipooligosaccharide was shown to exhibit carbohydrate structures analogous to the GM1a and GM2 carbohydrate epitopes of human gangliosides.The high Mr capsule polysaccharide was composed of β-d-Ribp, β-d-GalfNAc, α-d-GlcpA6(NGro), a uronic acid amidated with 2-amino-2-deoxyglycerol at C-6, and 6-O-methyl-d-glycero-α-l-gluco-heptopyranose as a side-branch. The structural information presented here will aid in the identification and characterization of specific enzymes that are involved in the biosynthesis of these structures and may lead to the discovery of potential therapeutic targets. In addition, the correlation of carbohydrate structure with gene complement will aid in the elucidation of the role of these surface carbohydrates in C. jejuni pathogenesis.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberSTMICHAEL2002
NPARC number9360878
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Record identifierc867dd4f-900c-4352-b49f-2cd61ca1b236
Record created2009-07-10
Record modified2016-05-09
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