Cancer systems biology in the genome sequencing era: Part 2, evolutionary dynamics of tumor clonal networks and drug resistance

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DOIResolve DOI: http://doi.org/10.1016/j.semcancer.2013.06.001
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TypeArticle
Journal titleSeminars in Cancer Biology
ISSN1044-579X
Volume23
Issue4
Pages286292; # of pages: 7
Subjectbioinformatics; cancer resistance; carcinogenesis; computer analysis; gene duplication; gene regulatory network; gene sequence; genetic association; genetic heterogeneity; genome analysis; genomics; human; malignant neoplastic disease; molecular cloning; molecular dynamics; molecular model; mutational analysis; nonhuman; review; RNA sequence; signal transduction; systems biology; tumor microenvironment
AbstractA tumor often consists of multiple cell subpopulations (clones). Current chemo-treatments often target one clone of a tumor. Although the drug kills that clone, other clones overtake it and the tumor recurs. Genome sequencing and computational analysis allows to computational dissection of clones from tumors, while singe-cell genome sequencing including RNA-Seq allows profiling of these clones. This opens a new window for treating a tumor as a system in which clones are evolving. Future cancer systems biology studies should consider a tumor as an evolving system with multiple clones. Therefore, topics discussed in Part 2 of this review include evolutionary dynamics of clonal networks, early-warning signals (e.g., genome duplication events) for formation of fast-growing clones, dissecting tumor heterogeneity, and modeling of clone-clone-stroma interactions for drug resistance. The ultimate goal of the future systems biology analysis is to obtain a 'whole-system' understanding of a tumor and therefore provides a more efficient and personalized management strategies for cancer patients. © 2013 Published by Elsevier Ltd.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21270739
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Record identifierc8ddc772-fba7-451f-bd33-a83e75639745
Record created2014-02-17
Record modified2016-05-09
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