Enantioselective Esterification of Racemic Ibuprofen in Solvent Media under Reduced Pressure

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DOIResolve DOI: http://doi.org/10.1002/(SICI)1097-4660(199706)69:2<266::AID-JCTB698>3.0.CO;2-6
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TypeArticle
Journal titleJournal of Chemical Technology & Biotechnology
Volume69
Issue2
Pages266270; # of pages: 5
AbstractThe enantioselective esterification of (R,S)-ibuprofen has been performed with Novozym 435TM in solvent media under reduced pressure. The nature of the solvent affects the activity and enantioselectivity of the lipase. High esterification rates are obtained in solvents having high hydrophobicity (log P>4). On the other hand, the best enantioselectivity is obtained with solvents having low hydrophobicity (log P<3). This particular enantioselectivity trend is observed within the individual solvent families investigated (alkanes, ethers and aromatics). � Canadian Crown Copyright 1997
Publication date
AffiliationNational Research Council Canada; NRC Biotechnology Research Institute
Peer reviewedNo
NPARC number12327710
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Record identifierca51be83-23df-4cd2-a8f6-7094529123a7
Record created2009-09-10
Record modified2016-05-09
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